Abstract
Replacement of the thiol groups in 1, a potent and highly selective Candida albicans GGTase I inhibitor discovered through screening, with an imidazole ring was achieved by using solid phase synthesis. A non-thiol compound, 7, was found as a representative of a new class of potent C. albicans GGTase I inhibitor with high selectivity against human GGTase I.
MeSH terms
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Antifungal Agents / chemistry
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Antifungal Agents / classification
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Antifungal Agents / pharmacology
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Candida albicans / enzymology
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Combinatorial Chemistry Techniques*
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Dipeptides
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / classification
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Enzyme Inhibitors / pharmacology*
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Humans
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Imidazoles
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Inhibitory Concentration 50
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Structure-Activity Relationship
Substances
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Antifungal Agents
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Dipeptides
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Enzyme Inhibitors
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Imidazoles
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imidazole